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The rise of CSC theory, some specific CSC markers were being discovered to identify putative CSCs, and ALDH1 is becoming to act as a CSC marker in the CSC studies of variable tumor types in vitro and in vivo. Epithelial-to-mesenchymal transition (EMT) is an important driver of tumor invasion and metastasis, which may be a feature of CSC. Compared to ALDH1(-) EMT cells, only ALDH1(+) EMT cells had
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Owever, there were other studies indicating a better clinical outcome in ALDH1(+) cancer patients, using different antibodies. Our previous study, using rabbit polyclonal antibody against human ALDH1A1 (ab63026, Abcam, Cambridge, UK) has proved that ALDH1 expression in vulvar squamous cell carcinomas predicted a significantly better survival than the ALDH1 negative cases [28]. Similarly, Hessman a
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Observe a empiricist philosophy posi
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T) and have less differentiation prospective than ESCs. Distinct from ESCs, ASCs are usually not capable of limitless expansion in vitro. ASC potency and plasticity is still in contention, though [11,22,43]. ASCs contain mesenchymal stem cells (MSCs), hematopoietic stem cells (HSCs), epithelial and neural stem cells, and other individuals. HSCs and MSCs originate inside the bone marrow (MSCs might
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