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. Later, with improvements in genome-wide tiling microarrays, and ultimately RNA-sequencing (RNA-seq), it became clear that a huge number of lncRNAs exist, and these are very regulated in cells. These lncRNAs are polyadenylated, spliced, and show very tissue-specific patterns of expression.54,61,62 Even though the function for most of those lncRNAs is still not recognized (or if all are even funct