Ndocrine function. Thus, restoring the standard cytokine profile in endocrine pancreas and plasma might hold fantastic promise for extra effective beta-cell dysfunction treatment and T2DM management. de Lemos et al. [92] has demonstrated, making use of the ZDF rat as animal model of obese T2DM, that exercise training was in a position to stop accumulation of pro-inflammatory cytokines (IL-6 and TN