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Starkie et al. showed that physical exercising directly inhibits endotoxin-induced TNF- production in humans, probably via IL-6 release from exercising muscle [136]. Usually, IL-6 will be the first cytokine present in circulation right after physical exercise practice, followed by a rise in IL-1ra and IL-10 [137]. The ubiquitous function of IL-6 along with the hypothesis of an exercise-induced ant