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The antibody is targeting a special epitope on the good antigens. All HLA-DRB1 epitopes had been defined utilizing solely amino acid sequence information, in contrast to HLA-DQA1, HLA-DQB1, and HLA-DPB1 epitopes that have been defined using human alloantibodies. Lastly, we defined and reported on 7 MICA epitopes utilizing human alloantibodies [15, 22]. In this paper, we give a summary of our findi