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Middle6waste

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The rise of CSC theory, some specific CSC markers were being discovered to identify putative CSCs, and ALDH1 is becoming to act as a CSC marker in the CSC studies of variable tumor types in vitro and in vivo. Epithelial-to-mesenchymal transition (EMT) is an important driver of tumor invasion and metastasis, which may be a feature of CSC. Compared to ALDH1(-) EMT cells, only ALDH1(+) EMT cells had
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Owever, there were other studies indicating a better clinical outcome in ALDH1(+) cancer patients, using different antibodies. Our previous study, using rabbit polyclonal antibody against human ALDH1A1 (ab63026, Abcam, Cambridge, UK) has proved that ALDH1 expression in vulvar squamous cell carcinomas predicted a significantly better survival than the ALDH1 negative cases [28]. Similarly, Hessman a
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Nt years [32]. In their study, dual positive cells of ALDH1 and another traditional ovarian CSC marker CD133 were isolated directly from human tumor to initiate tumor in mice, and these cells displayed enhanced angiogenesis and tumorigenicity like other CSCs [32]. Moreover, the patients with CD133(+)/ALDH1(+) tumor cells displayed reduced PFS and OS [32]. Distinct expression levels and patterns of
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Ay, and the inhibition of ALDH1-mediated retinoid signaling impairs human fetal islet cell differentiation and survival [5]. It is also known that cancer stem cells share features of normal stem cells. Therefore, it can't be excluded in the ovarian cancer cells that ALDH1 exerts its role through the same molecular mechanism, by such contributing to the better survival in ovarian cancers, although
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Tion, and return home healthy.John D Grabenstein deputy director Military Vaccine Agency, 5113 Leesburg Pike, Suite 402, Falls Church, VA 22041 USA john.grabenstein@us.army.mil William Winkenwerder Jr assistant secretary of defense (health affairs) Washington, DC, USA5 Eckart RE, Love SS, Atwood JE, Arness MK, Cassimatis DC, Campbell CL, et al. Incidence and follow-up of inflammatory cardiac compl
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Tion, and return home healthy.John D Grabenstein deputy director Military Vaccine Agency, 5113 Leesburg Pike, Suite 402, Falls Church, VA 22041 USA john.grabenstein@us.army.mil William Winkenwerder Jr assistant secretary of defense (health affairs) Washington, DC, USA5 Eckart RE, Love SS, Atwood JE, Arness MK, Cassimatis DC, Campbell CL, et al. Incidence and follow-up of inflammatory cardiac compl
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Tion, and return home healthy.John D Grabenstein deputy director Military Vaccine Agency, 5113 Leesburg Pike, Suite 402, Falls Church, VA 22041 USA john.grabenstein@us.army.mil William Winkenwerder Jr assistant secretary of defense (health affairs) Washington, DC, USA5 Eckart RE, Love SS, Atwood JE, Arness MK, Cassimatis DC, Campbell CL, et al. Incidence and follow-up of inflammatory cardiac compl
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He University of Texas MD Anderson Cancer Center. In their long-term follow-up study, The same mouse monoclonal anti-human ALDH Clone 44 from BD Transduction LaboratoriesTM was used, and it turned out that high level of ALDH1 was detected in 19 out of the total 442 ovarian carcinoma samples, and it was significantly associated with endometrioid adenocarcinoma, early-stage tumor, complete respons